Ubiquitylation-dependent localization of PLK1 in mitosis

  title={Ubiquitylation-dependent localization of PLK1 in mitosis},
  author={Jochen Beck and Sarah Maerki and Markus Posch and Thibaud Metzger and Avinash D Persaud and Hartmut Scheel and Kay Hofmann and Daniela Rotin and Patrick G. A. Pedrioli and Jason R. Swedlow and Matthias Peter and Izabela Sumara},
  journal={Nature Cell Biology},
Polo-like kinase 1 (PLK1) critically regulates mitosis through its dynamic localization to kinetochores, centrosomes and the midzone. The polo-box domain (PBD) and activity of PLK1 mediate its recruitment to mitotic structures, but the mechanisms regulating PLK1 dynamics remain poorly understood. Here, we identify PLK1 as a target of the cullin 3 (CUL3)-based E3 ubiquitin ligase, containing the BTB adaptor KLHL22, which regulates chromosome alignment and PLK1 kinetochore localization but not… CONTINUE READING