Ubiquitylation and the pathogenesis of hypertension.

  title={Ubiquitylation and the pathogenesis of hypertension.},
  author={David H Ellison},
  journal={The Journal of clinical investigation},
  volume={123 2},
Liddle syndrome is monogenic hypertension caused by mutations in the epithelial Na+ channel (ENaC) that interfere with its ubiquitylation by Nedd4-2. In this issue, Ronzaud and colleagues found that deleting Nedd4-2 from kidney tubules in adult mice led to ENaC accumulation, but not at the plasma membrane, as predicted from current models. Instead, abundance of the sodium chloride transporter NCC increased at the plasma membrane, and the mice have some features of increased NCC activity… CONTINUE READING

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