Ubiquitylation and activation of a Rab GTPase is promoted by a β₂AR-HACE1 complex.

@article{Lachance2014UbiquitylationAA,
  title={Ubiquitylation and activation of a Rab GTPase is promoted by a β₂AR-HACE1 complex.},
  author={V{\'e}ronik Lachance and Jade Degrandmaison and S{\'e}bastien Marois and M{\'e}lanie Robitaille and Samuel G{\'e}nier and St{\'e}phanie Nadeau and St{\'e}phane Angers and Jean-Luc Parent},
  journal={Journal of cell science},
  year={2014},
  volume={127 Pt 1},
  pages={
          111-23
        }
}
We and others have shown that trafficking of G-protein-coupled receptors is regulated by Rab GTPases. Cargo-mediated regulation of vesicular transport has received great attention lately. Rab GTPases, which form the largest branch of the Ras GTPase superfamily, regulate almost every step of vesicle-mediated trafficking. Rab GTPases are well-recognized targets of human diseases but their regulation and the mechanisms connecting them to cargo proteins are still poorly understood. Here, we show by… CONTINUE READING

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