Ubiquitylation, neddylation and the DNA damage response

@inproceedings{Brown2015UbiquitylationNA,
  title={Ubiquitylation, neddylation and the DNA damage response},
  author={Jessica S. Brown and Stephen P. Jackson},
  booktitle={Open biology},
  year={2015}
}
Failure of accurate DNA damage sensing and repair mechanisms manifests as a variety of human diseases, including neurodegenerative disorders, immunodeficiency, infertility and cancer. The accuracy and efficiency of DNA damage detection and repair, collectively termed the DNA damage response (DDR), requires the recruitment and subsequent post-translational modification (PTM) of a complex network of proteins. Ubiquitin and the ubiquitin-like protein (UBL) SUMO have established roles in regulating… CONTINUE READING
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