Ubiquitous transcription factors display structural plasticity and diverse functions: NusG proteins - Shifting shapes and paradigms.

@article{NandyMazumdar2015UbiquitousTF,
  title={Ubiquitous transcription factors display structural plasticity and diverse functions: NusG proteins - Shifting shapes and paradigms.},
  author={Monali NandyMazumdar and Irina Artsimovitch},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  year={2015},
  volume={37 3},
  pages={324-34}
}
Numerous accessory factors modulate RNA polymerase response to regulatory signals and cellular cues and establish communications with co-transcriptional RNA processing. Transcription regulators are astonishingly diverse, with similar mechanisms arising via convergent evolution. NusG/Spt5 elongation factors comprise the only universally conserved and ancient family of regulators. They bind to the conserved clamp helices domain of RNA polymerase, which also interacts with non-homologous… CONTINUE READING
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