Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

@article{Ionov1993UbiquitousSM,
  title={Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis},
  author={Yurij Ionov and Mar{\'i}a Angeles Peinado and Sergei R. Malkhosyan and Darryl Shibata and Manuel Perucho},
  journal={Nature},
  year={1993},
  volume={363},
  pages={558-561}
}
SPONTANEOUS errors in DNA replication have been suggested to play a significant role in neoplastic transformation and to explain the chromosomal alterations seen in cancer cells1. A defective replication factor could increase the mutation rate in clonal variants arising during tumour progression, but despite intensive efforts, increases in tumour cell mutation rates have not been unambiguously shown2. Here we use an unbiased genomic fingerprinting technique3 to show that 12 per cent of… 
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