Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

@article{Ionov1993UbiquitousSM,
  title={Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis},
  author={Y. Ionov and Mar{\'i}a Angeles Peinado and S. Malkhosyan and D. Shibata and M. Perucho},
  journal={Nature},
  year={1993},
  volume={363},
  pages={558-561}
}
SPONTANEOUS errors in DNA replication have been suggested to play a significant role in neoplastic transformation and to explain the chromosomal alterations seen in cancer cells1. A defective replication factor could increase the mutation rate in clonal variants arising during tumour progression, but despite intensive efforts, increases in tumour cell mutation rates have not been unambiguously shown2. Here we use an unbiased genomic fingerprinting technique3 to show that 12 per cent of… Expand
Genomic Instability and Carcinogenesis: An Update
Pathogenesis of DNA repair-deficient cancers: a statistical meta-analysis of putative Real Common Target genes
Extensive characterization of genetic alterations in a series of human colorectal cancer cell lines
Genetic alterations in colorectal cancer, comparative analysis of deletion events, and point mutations.
Mutations and epimutations in the origin of cancer.
Human cancers express a mutator phenotype
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