Ubiquitous receptor: a receptor that modulates gene activation by retinoic acid and thyroid hormone receptors.

@article{Song1994UbiquitousRA,
  title={Ubiquitous receptor: a receptor that modulates gene activation by retinoic acid and thyroid hormone receptors.},
  author={C Song and John M. Kokontis and Richard A. Hiipakka and S Liao},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 23},
  pages={10809-13}
}
  • C Song, John M. Kokontis, +1 author S Liao
  • Published 1994 in
    Proceedings of the National Academy of Sciences…
The cDNA for a member of the nuclear receptor family was cloned and named ubiquitous receptor (UR), since UR protein and mRNA are detected in many cell types. Rat UR/human retinoid X receptor alpha (hRXR alpha) heterodimers bound preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence AGGTCA and 4-nt spacing (DR-4). Coexpression of UR in COS-1 cells inhibited the stimulation of chloramphenicol acetyltransferase (CAT) reporter gene expression by… CONTINUE READING