Ubiquitous expression of human SCA2 gene under the regulation of the SCA2 self promoter cause specific Purkinje cell degeneration in transgenic mice.

@article{Aguiar2006UbiquitousEO,
  title={Ubiquitous expression of human SCA2 gene under the regulation of the SCA2 self promoter cause specific Purkinje cell degeneration in transgenic mice.},
  author={Jorge T. Aguiar and Julio Fern{\'a}ndez and Anselmo Aguilar and Yssel Mendoza and Maria Fernanda Chein V{\'a}zquez and Jose J Suarez and Jorge Berlanga and Silian Cruz and Gerardo Guill{\'e}n and Luis H. Herrera and Lu{\'i}s Vel{\'a}zquez and Nieves Santos and Nelson Merino},
  journal={Neuroscience letters},
  year={2006},
  volume={392 3},
  pages={202-6}
}
The objective of this work was the generation of an animal model of the SCA2 disease for future studies on the benefits of therapeutic molecules and neuropathological mechanisms that underline this human disorder. The transgenic fragment was microinjected into pronuclei of B6D2F1 X OF1 mouse hybrid strain. For Northern blots, RNAs were hybridized with a human cDNA fragment from the SCA2 gene and a mouse beta-actin cDNA fragment. Monoclonal antibody directed to the N-terminal of the ataxin 2… CONTINUE READING

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