Ubiquitous Chromatin-opening Elements (UCOEs): Applications in biomanufacturing and gene therapy.

@article{Neville2017UbiquitousCE,
  title={Ubiquitous Chromatin-opening Elements (UCOEs): Applications in biomanufacturing and gene therapy.},
  author={Jonathan James Neville and Joe Orlando and Kimberly Ann Mann and Bethany Mccloskey and Michael N Antoniou},
  journal={Biotechnology advances},
  year={2017},
  volume={35 5},
  pages={
          557-564
        }
}
Ubiquitous Chromatin-opening Elements (UCOEs) are defined by their ability to consistently confer stable, site of integration-independent transgene expression that is proportional to copy number, including from within regions of heterochromatin such as centromeres. UCOEs structurally consist of methylation-free CpG islands encompassing single or dual divergently-transcribed housekeeping gene promoters. Since their discovery in 1999, UCOEs and their sub-fragments have found applications in areas… CONTINUE READING
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