Ubiquitous, interspersed repeated sequences in mammalian genomes.

  title={Ubiquitous, interspersed repeated sequences in mammalian genomes.},
  author={Warren Jelinek and T P Toomey and Leslie A. Leinwand and Craig H. Duncan and P. A. Biro and Prabhakara V. Choudary and Sherman Morton Weissman and Carol M. Rubin and Cathy Houck and Prescott L Deininger and Carl W. Schmid},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={77 3},
DNA base sequence comparisons demonstrate that the principal family of 300-nucleotide interspersed human DNA sequences, the repetitive double-strand regions of HeLa cell heterogeneous nuclear RNA, and specific RNA polymerase III in vitro transcripts of cloned human DNA sequences are all representatives of a closely related family of sequences. A segment of approximately 30 residues of these sequences is highly conserved in mammalian evolution because it is also present in the interspersed… 
Highly repeated sequences in mammalian genomes.
  • M. Singer
  • Biology
    International review of cytology
  • 1982
The evolution of a family of short interspersed repeats in primate DNA
This work examines the evolution of this family of sequences in primates and finds that Bonnet monkey (Macaque radiata) DNA contains a predominant family of 300 nucleotide repeats which has nearly the same restriction map as the human AlU family and which hybridizes to human Alu family repeats under Southern blotting conditions.
Bovine DNA contains a single major family of interspersed repetitive sequences.
A major family of short, interspersed, repeated sequences in the bovine genome has been characterized and shows that this family includes sequences reported previously by Watanabe et al. and is distantly related to the human Alu sequence family.
Properties of dispersed, highly repeated DNA within and near the hamster CAD gene
Dispersed, highly repeated DNA sequences were found within and near the Syrian hamster gene coding for the multifunctional protein CAD, and the hamster sequences were homologous to total repetitive human DNA but only very weakly homological to two cloned members of the human Alu family.
Small RNA molecules related to the Alu family of repetitive DNA sequences
It is shown that the rat 4.5S RNA is part of a small family of RNA molecules, all sharing sequence homology to the Alu family of DNA sequences, which are synthesized by RNA polymerase III and are developmentally regulated and short-lived in the cytoplasm.
Isolation and characterization of human DNA fragments with nucleotide sequence homologies with the simian virus 40 regulatory region
A recombinant library of human DNA sequences was screened with a segment of simian virus 40 (SV40) DNA that spans the viral origin of replication and it is proposed that this segment of DNA contains a sequence analogous to the 72-base-pair repeats of SV40.
A cytomegalovirus DNA sequence containing tracts of tandemly repeated CA dinucleotides hybridizes to highly repetitive dispersed elements in mammalian cell genomes
It is concluded that discrete, tandemly repeated dinucleotide tracts capable of forming left-handed Z-DNA helices punctuate mammalian genomes at greater than 10(5) copies per cell and that three adjacent copies of what appear to be a family of interspersed repetitive elements containing these (CA)n stretches are carried in the genomes of simian cytomegaloviruses.