Ubiquitination on nonlysine residues by a viral E3 ubiquitin ligase.

  title={Ubiquitination on nonlysine residues by a viral E3 ubiquitin ligase.},
  author={Ken Cadwell and Laurent Coscoy},
  volume={309 5731},
Ubiquitination controls a broad range of cellular functions. The last step of the ubiquitination pathway is regulated by enzyme type 3 (E3) ubiquitin ligases. E3 enzymes are responsible for substrate specificity and catalyze the formation of an isopeptide bond between a lysine residue of the substrate (or the N terminus of the substrate) and ubiquitin. MIR1 and MIR2 are two E3 ubiquitin ligases encoded by Kaposi's sarcoma-associated herpesvirus that mediate the ubiquitination of major… CONTINUE READING

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Lane: 1 2 3 4 Ubiquitin-bound E2E3 HA-E2E3: - + - + pH 8 pH

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