Ubiquitination of retinoblastoma family protein 1 potentiates gene-specific repression function.

Abstract

The retinoblastoma (RB) tumor suppressor family functions as a regulatory node governing cell cycle progression, differentiation, and apoptosis. Post-translational modifications play a critical role in modulating RB activity, but additional levels of control, including protein turnover, are also essential for proper function. The Drosophila RB homolog Rbf1… (More)
DOI: 10.1074/jbc.M112.422428

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