Corpus ID: 44015625

Ubiquitination of p 53 at Multiple Sites in the DNA-Binding Domain

@inproceedings{Chan2006UbiquitinationOP,
  title={Ubiquitination of p 53 at Multiple Sites in the DNA-Binding Domain},
  author={Wan Chan and M. Mak and T. Fung and A. Lau and W. Y. Siu and R. Poon},
  year={2006}
}
The tumor suppressor p53 is negatively regulated by the ubiquitin ligase MDM2. The MDM2 recognition site is at the NH2-terminal region of p53, but the positions of the actual ubiquitination acceptor sites are less well defined. Lysine residues at the COOH-terminal region of p53 are implicated as sites for ubiquitination and other post-translational modifications. Unexpectedly, we found that substitution of the COOH-terminal lysine residues did not diminish MDM2-mediated ubiquitination… Expand

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