Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast

@article{Sun2002UbiquitinationOH,
  title={Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast},
  author={Zu-Wen Sun and C. David Allis},
  journal={Nature},
  year={2002},
  volume={418},
  pages={104-108}
}
In eukaryotes, the DNA of the genome is packaged with histone proteins to form nucleosomal filaments, which are, in turn, folded into a series of less well understood chromatin structures. Post-translational modifications of histone tail domains modulate chromatin structure and gene expression. Of these, histone ubiquitination is poorly understood. Here we show that the ubiquitin-conjugating enzyme Rad6 (Ubc2) mediates methylation of histone H3 at lysine 4 (Lys 4) through ubiquitination of H2B… 

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