• Medicine
  • Published in Autophagy 2008

Ubiquitination of alpha-synuclein and autophagy in Parkinson's disease.

@article{Engelender2008UbiquitinationOA,
  title={Ubiquitination of alpha-synuclein and autophagy in Parkinson's disease.},
  author={Simone Engelender},
  journal={Autophagy},
  year={2008},
  volume={4 3},
  pages={
          372-4
        }
}
alpha-Synuclein is mutated in Parkinson's disease (PD) and is found in cytosolic inclusions, called Lewy bodies, in sporadic forms of the disease. A fraction of alpha-synuclein purified from Lewy bodies is monoubiquitinated, but the role of this monoubiquitination has been obscure. We now review recent data indicating a role of alpha-synuclein monoubiquitination in Lewy body formation and implicating the autophagic pathway in regulating these processes. The E3 ubiquitin-ligase SIAH is present… CONTINUE READING

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