Ubiquitination of PCNA and the polymerase switch in human cells.

  title={Ubiquitination of PCNA and the polymerase switch in human cells.},
  author={Patricia L. Kannouche and A. R. Lehmann},
  journal={Cell cycle},
  volume={3 8},
Replicative DNA polymerases are blocked by damage in the template DNA. To get past this damage, the cell employs specialized translesion synthesis (TLS) polymerases, which have reduced stringency and are able to bypass different lesions. For example, DNA polymerase eta (poleta) is able to carry out TLS past UV-induced cyclobutane pyrimidine dimers. How does the cell bring about the switch from replicative to TLS polymerase? We have shown that, in human cells, when the replication machinery is… CONTINUE READING


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