Ubiquitination of CD86 is a key mechanism in regulating antigen presentation by dendritic cells.

Abstract

Dendritic cells (DCs) require costimulatory molecules such as CD86 to efficiently activate T cells for the induction of adaptive immunity. DCs maintain minimal levels of CD86 expression at rest, but upregulate levels upon LPS stimulation. LPS-stimulated DCs produce the immune suppressive cytokine IL-10 that acts in an autocrine manner to regulate CD86… (More)
DOI: 10.4049/jimmunol.1101643

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