Ubiquitination of ABCE1 by NOT4 in Response to Mitochondrial Damage Links Co-translational Quality Control to PINK1-Directed Mitophagy.

@article{Wu2018UbiquitinationOA,
  title={Ubiquitination of ABCE1 by NOT4 in Response to Mitochondrial Damage Links Co-translational Quality Control to PINK1-Directed Mitophagy.},
  author={Z. Wu and Y. Wang and Junghyun Lim and B. Liu and Y. Li and R. Vartak and Trisha R. Stankiewicz and S. Montgomery and B. Lu},
  journal={Cell metabolism},
  year={2018},
  volume={28 1},
  pages={
          130-144.e7
        }
}
Translation of mRNAs is tightly regulated and constantly surveyed for errors. Aberrant translation can trigger co-translational protein and RNA quality control processes, impairments of which cause neurodegeneration by still poorly understood mechanism(s). Here we show that quality control of translation of mitochondrial outer membrane (MOM)-localized mRNA intersects with the turnover of damaged mitochondria, both orchestrated by the mitochondrial kinase PINK1. Mitochondrial damage causes… Expand
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