Ubiquitination of ABCE1 by NOT4 in Response to Mitochondrial Damage Links Co-translational Quality Control to PINK1-Directed Mitophagy.

@article{Wu2018UbiquitinationOA,
  title={Ubiquitination of ABCE1 by NOT4 in Response to Mitochondrial Damage Links Co-translational Quality Control to PINK1-Directed Mitophagy.},
  author={Zhihao Wu and Yan Wang and Junghyun Lim and Boxiang Liu and Yanping Li and Rasika Vartak and Trisha Stankiewicz and Stephen B. Montgomery and Bingwei Lu},
  journal={Cell metabolism},
  year={2018},
  volume={28 1},
  pages={
          130-144.e7
        }
}
Translation of mRNAs is tightly regulated and constantly surveyed for errors. Aberrant translation can trigger co-translational protein and RNA quality control processes, impairments of which cause neurodegeneration by still poorly understood mechanism(s). Here we show that quality control of translation of mitochondrial outer membrane (MOM)-localized mRNA intersects with the turnover of damaged mitochondria, both orchestrated by the mitochondrial kinase PINK1. Mitochondrial damage causes… CONTINUE READING