Ubiquitination and proteasomal degradation of the BRCA1 tumor suppressor is regulated during cell cycle progression.

@article{Choudhury2004UbiquitinationAP,
  title={Ubiquitination and proteasomal degradation of the BRCA1 tumor suppressor is regulated during cell cycle progression.},
  author={Atish D Choudhury and Hong Xu and Richard D. Baer},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 32},
  pages={33909-18}
}
The BRCA1 tumor suppressor and the BARD1 protein form a stable heterodimeric complex that can catalyze the formation of polyubiquitin chains. Expression of BRCA1 fluctuates in a cell cycle-dependent manner, such that low steady-state levels of BRCA1 gene products are found in resting cells and early G1 cycling cells and high levels in S and G2 phase cells. Although transcriptional activation of the BRCA1 gene can account for induction of BRCA1 expression at the G1/S transition, the mechanisms… CONTINUE READING
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