Ubiquitination and degradation of GBPs by a Shigella effector to suppress host defence

@article{Li2017UbiquitinationAD,
  title={Ubiquitination and degradation of GBPs by a Shigella effector to suppress host defence},
  author={Peng P. Li and Wei Jiang and Qin Yu and W. D. Liu and Ping Zhou and Jun Li and Junjie Xu and Bo Xu and Fengchao Wang and Feng Shao},
  journal={Nature},
  year={2017},
  volume={551},
  pages={378-383}
}
Interferon-inducible guanylate-binding proteins (GBPs) mediate cell-autonomous antimicrobial defences. Shigella flexneri, a Gram-negative cytoplasmic free-living bacterium that causes bacillary dysentery, encodes a repertoire of highly similar type III secretion system effectors called invasion plasmid antigen Hs (IpaHs). IpaHs represent a large family of bacterial ubiquitin-ligases, but their function is poorly understood. Here we show that S. flexneri infection induces rapid proteasomal… CONTINUE READING
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