Ubiquitinated pathological lesions in frontotemporal lobar degeneration contain the TAR DNA-binding protein, TDP-43

@article{Davidson2006UbiquitinatedPL,
  title={Ubiquitinated pathological lesions in frontotemporal lobar degeneration contain the TAR DNA-binding protein, TDP-43},
  author={Yvonne Davidson and Thomas Kelley and Ian R. A. Mackenzie and Stuart M. Pickering-Brown and Daniel du Plessis and David Neary and Julie S. Snowden and David M A Mann},
  journal={Acta Neuropathologica},
  year={2006},
  volume={113},
  pages={521-533}
}
We have investigated the extent and pattern of immunostaining for the TAR DNA-binding protein, TDP-43, in 37 patients with frontotemporal lobar degeneration with ubiquitin (UBQ) pathology (FTLD-U). We confirm that TDP-43 protein is a component of the UBQ immunoreactive (UBQ-ir) neuronal cytoplasmic inclusions (NCI), neuronal intranuclear inclusions (NII) and neurites of the cerebral cortex and hippocampus in FTLD-U. We further show that the same three histological patterns, previously… CONTINUE READING
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