Ubiquitin systems mark pathogen-containing vacuoles as targets for host defense by guanylate binding proteins.

@article{Haldar2015UbiquitinSM,
  title={Ubiquitin systems mark pathogen-containing vacuoles as targets for host defense by guanylate binding proteins.},
  author={Arun Kumar Haldar and Cl{\'e}mence Foltz and Ryan H. Finethy and Anthony S. Piro and Eric M. Feeley and Danielle M Pilla-Moffett and Masaki Komatsu and Eva-Maria Frickel and J{\"o}rn Coers},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 41},
  pages={E5628-37}
}
Many microbes create and maintain pathogen-containing vacuoles (PVs) as an intracellular niche permissive for microbial growth and survival. The destruction of PVs by IFNγ-inducible guanylate binding protein (GBP) and immunity-related GTPase (IRG) host proteins is central to a successful immune response directed against numerous PV-resident pathogens. However, the mechanism by which IRGs and GBPs cooperatively detect and destroy PVs is unclear. We find that host cell priming with IFNγ prompts… CONTINUE READING
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