Ubiquitin specific proteases USP24 and USP40 and ubiquitin thiolesterase UCHL1 polymorphisms have synergic effect on the risk of Parkinson's disease among Taiwanese.

@article{Wu2010UbiquitinSP,
  title={Ubiquitin specific proteases USP24 and USP40 and ubiquitin thiolesterase UCHL1 polymorphisms have synergic effect on the risk of Parkinson's disease among Taiwanese.},
  author={Yih-Ru Wu and Chiung-Mei Chen and Yi-chun Chen and Chih-Ying Chao and Long Sun Ro and Hon Chung Fung and Ya-Chin Hsiao and Fen-Ju Hu and Guey-Jen Lee-Chen},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  year={2010},
  volume={411 13-14},
  pages={955-8}
}
BACKGROUND Impaired ubiquitin-proteasome system function may contribute to the pathogenesis of Parkinson's disease (PD). METHODS We conducted a case-control study in a cohort of 517 PD cases and 518 ethnically matched controls to investigate the association of ubiquitin specific proteases USP24 rs487230 C>T, USP40 rs1048603 C>T, and ubiquitin thiolesterase UCHL1 rs5030732 A>C polymorphisms with the risk of PD. RESULTS No significant difference in the genotype or allele distribution was… CONTINUE READING