Ubiquitin-specific protease 2-69 in macrophages potentially modulates metainflammation.

  title={Ubiquitin-specific protease 2-69 in macrophages potentially modulates metainflammation.},
  author={Hiroshi Kitamura and Shunsuke Kimura and Yoshinori Shimamoto and Jun Okabe and Masatoshi Ito and Tomomi Miyamoto and Yoshinori Naoe and Chisato Kikuguchi and Bob Meek and Chitoku Toda and Shiki Okamoto and Katsushi Kanehira and Koji Hase and Hiroshi Watarai and Mayumi Ishizuka and Assam El-Osta and Osamu Ohara and Ichiro Miyoshi},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={27 12},
Macrophages play a critical role in chronic inflammation and metabolic diseases. We identified a longer splice variant of ubiquitin specific protease (USP) 2-69 as a novel molecule that modulates pathways implicated in metabolic disorders. Expression levels of aP2/FABP4 and PAI-1/SERPINE1 genes were increased by 4- and 1.8-fold, respectively, after short hairpin RNA-mediated knockdown (KD) of the USP2 gene, and such expression was alleviated by overexpression of USP2-69 in human myeloid cell… CONTINUE READING


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