Ubiquitin-specific protease 13 regulates IFN signaling by stabilizing STAT1.

  title={Ubiquitin-specific protease 13 regulates IFN signaling by stabilizing STAT1.},
  author={Hom-Ming Yeh and Chia-Yi Yu and Ho-Chun Yang and Shih-Han Ko and Ching-Len Liao and Yi-Ling Lin},
  journal={Journal of immunology},
  volume={191 6},
The IFN immune system comprises type I, II, and III IFNs, signals through the JAK-STAT pathway, and plays central roles in host defense against viral infection. Posttranslational modifications such as ubiquitination regulate diverse molecules in the IFN pathway. To search for the deubiquitinating enzymes (DUBs) involved in the antiviral activity of IFN, we used RNA interference screening to identify a human DUB, ubiquitin-specific protease (USP) 13, whose expression modulates the antiviral… CONTINUE READING
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