Ubiquitin removal in the TGF-β pathway

  title={Ubiquitin removal in the TGF-β pathway},
  author={Kamna Aggarwal and Joan Massagu{\'e}},
  journal={Nature Cell Biology},
The transforming growth factor (TGF-β) pathway is regulated by ubiquitin-mediated proteolysis at different levels. Two studies now identify deubiquitinating enzymes (DUBs) for the TGF-β type I receptor. Both ubiquitin-specific peptidase-4 (USP4) and -15 (USP15) extend the life of activated receptors against the negative pressure of receptor-ubiquitinating complexes, but through distinct modes of action.