Ubiquitin receptor binding and signaling in primary human leukocytes.

  title={Ubiquitin receptor binding and signaling in primary human leukocytes.},
  author={Vikas Saini and Jacqueline Romero and Adriano Marchese and Matthias Majetschak},
  journal={Communicative & integrative biology},
  volume={3 6},
Utilizing the human monocyte/macrophage cell line THP1, we recently identified extracellular ubiquitin as an endogenous agonist of the G protein-coupled receptor CXC chemokine receptor (CXCR) 4. Because receptor binding and signaling properties of extracellular ubiquitin have not been evaluated in primary human leukocytes, we analyzed its binding characteristics and subsequent Ca(2+) signaling in freshly isolated human B cells, T cells and monocytes. Ubiquitin binding shows typical receptor… CONTINUE READING
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