Ubiquitin-protein ligases in muscle wasting.

  title={Ubiquitin-protein ligases in muscle wasting.},
  author={Pei Rang Cao and Hannah J Kim and Stewart H. Lecker},
  journal={The international journal of biochemistry & cell biology},
  volume={37 10},
Muscle wasting occurs when rates of protein degradation outstrip rates of protein synthesis. Accelerated rates of protein degradation develop in atrophying muscle largely through activation of the ubiquitin-proteasome pathway. The complexity of the ubiquitination process, however, has hampered our understanding of how this pathway is activated in atrophying muscles and which enzymes of the ubiquitin conjugation system are responsible. Recent studies demonstrate that two ubiquitin-protein… CONTINUE READING

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