Ubiquitin protein ligase Nedd4 binds to connexin43 by a phosphorylation-modulated process.

@article{Leykauf2006UbiquitinPL,
  title={Ubiquitin protein ligase Nedd4 binds to connexin43 by a phosphorylation-modulated process.},
  author={Kerstin Leykauf and Mojibrahman Salek and Joerg Bomke and Matthias Frech and W. P. Lehmann and Matthias D{\"u}rst and {\'A}ngel Alonso},
  journal={Journal of cell science},
  year={2006},
  volume={119 Pt 17},
  pages={3634-42}
}
Connexin43 is degraded by the proteasomal as well as the lysosomal pathway with ubiquitin playing a role in both degradation pathways. So far, no ubiquitin protein ligase has been identified for any of the connexins. By using pull-down assays, here we show binding of a ubiquitin protein ligase, Nedd4, to the C-terminus of connexin43. This observation was confirmed in vivo by coimmunoprecipitation and immunofluorescence, showing colocalization of Nedd4 and connexin43. Binding of Nedd4 to its… CONTINUE READING
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