Ubiquitin proteasome system-mediated degradation of synaptic proteins: An update from the postsynaptic side.

@article{Tsai2014UbiquitinPS,
  title={Ubiquitin proteasome system-mediated degradation of synaptic proteins: An update from the postsynaptic side.},
  author={Nien-Pei Tsai},
  journal={Biochimica et biophysica acta},
  year={2014},
  volume={1843 12},
  pages={2838-2842}
}
The ubiquitin proteasome system is one of the principle mechanisms for the regulation of protein homeostasis in mammalian cells. In dynamic cellular structures such as neuronal synapses, ubiquitin proteasome system and protein translation provide an efficient way for cells to respond promptly to local stimulation and regulate neuroplasticity. The majority of research related to long-term plasticity has been focused on the postsynapses and has shown that ubiquitination and subsequent degradation… CONTINUE READING

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