Ubiquitin-proteasome system dysfunction in experimental models of Parkinson ' s disease

Abstract

The present study investigates cellular mechanisms underlying the pathogenic role of ubiquity proteasome system (UPS) dysfunction in dopaminergic degeneration following exposure to Parkinsonian neurotoxins. Mutations or overproduction of α-synuclein have been shown to be associated with familial Parkinson’s disease (PD), and wild type αsynuclein is the… (More)

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