Ubiquitin proteasome pathway: implications and advances in cancer therapy.

  title={Ubiquitin proteasome pathway: implications and advances in cancer therapy.},
  author={Shimul A. Shah and Michael W. Potter and Mark P. Callery},
  journal={Surgical oncology},
  volume={10 1-2},
The degradation of most eukaryotic cells is controlled by the ubiquitin proteasome pathway. This pathway is responsible not only for the degradation of short and long-lived proteins but also tumor suppressors, transcription factors and cell cycle proteins. Altered degradation of these proteins is thought to promote cancer growth and spread. By contrast, inhibition of the proteasome would lead to cell cycle arrest and ultimately programmed cell death, or apoptosis. A structured review of the… CONTINUE READING


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