Ubiquitin-proteasome-mediated CREB repressor degradation during induction of long-term facilitation.

  title={Ubiquitin-proteasome-mediated CREB repressor degradation during induction of long-term facilitation.},
  author={Sudarshan C Upadhya and Thuy K. Smith and Ashok N. Hegde},
  journal={Journal of neurochemistry},
  volume={91 1},
Abstract Long-term facilitation in Aplysia and other forms of long-term memory in invertebrates and vertebrates require the gene expression cascade induced by cAMP-responsive element binding protein (CREB). Normally, gene expression by CREB is inhibited by repressors. The molecular mechanisms by which the repression is relieved are not understood. Our results show that Aplysia CREB repressor is a substrate for degradation by the ubiquitin-proteasome pathway. Treatment with the facilitatory… CONTINUE READING

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