Ubiquitin makes its mark on immune regulation.

  title={Ubiquitin makes its mark on immune regulation.},
  author={Barbara A Malynn and Averil Ma},
  volume={33 6},
Ubiquitination, the covalent attachment of ubiquitin molecules to proteins, is emerging as a widely utilized mechanism for rapidly regulating cell signaling. Recent studies indicate that ubiquitination plays potent roles in regulating a variety of signals in both innate and adaptive immune cells. Here, we will review recent studies of ubiquitin ligases, ubiquitin chain linkages, and ubiquitin binding proteins that highlight the diversity and specificity of ubiquitin dependent functions in… CONTINUE READING