Ubiquitin ligases: cell-cycle control and cancer

  title={Ubiquitin ligases: cell-cycle control and cancer},
  author={Keiichi I Nakayama and Keiko Nakayama},
  journal={Nature Reviews Cancer},
A driving force of the cell cycle is the activation of cyclin-dependent kinases (CDKs), the activities of which are controlled by the ubiquitin-mediated proteolysis of key regulators such as cyclins and CDK inhibitors. Two ubiquitin ligases, the SKP1–CUL1–F-box-protein (SCF) complex and the anaphase-promoting complex/cyclosome (APC/C), are responsible for the specific ubiquitylation of many of these regulators. Deregulation of the proteolytic system might result in uncontrolled proliferation… CONTINUE READING
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A role for the anaphase-promoting complex inhibitor Emi2/XErp1, a homolog of early mitotic inhibitor 1, in cytostatic factor arrest of Xenopus eggs

  • Tung, J J.
  • Proc. Natl Acad. Sci. USA
  • 2005

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