Ubiquitin ligase Ufd2 is required for efficient degradation of Mps1 kinase.

@article{Liu2011UbiquitinLU,
  title={Ubiquitin ligase Ufd2 is required for efficient degradation of Mps1 kinase.},
  author={Chang Liu and D Schalk van Dyk and Vitnary Choe and Jing Jing Yan and Shubhra Majumder and Michael Costanzo and Xin Bao and Charles Boone and Keke Huo and Mark Winey and Harold A. Fisk and Brenda Andrews and H. S. Rao},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 51},
  pages={43660-7}
}
Ufd2 is a U-box-containing ubiquitylation enzyme that promotes ubiquitin chain assembly on substrates. The physiological function of Ufd2 remains poorly understood. Here, we show that ubiquitylation and degradation of the cell cycle kinase Mps1, a known target of the anaphase-promoting complex E3, require Ufd2 enzyme. Yeast cells lacking UFD2 exhibit altered chromosome stability and several spindle-related phenotypes, expanding the biological function of Ufd2. We demonstrate that Ufd2-mediated… CONTINUE READING

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