Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability

@inproceedings{Meisenberg2012UbiquitinLU,
  title={Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability},
  author={Cornelia Meisenberg and Phillip S Tait and Irina I. Dianova and Katherine Fairfax Wright and Mariola J Edelmann and Nicola Ternette and Takafumi Tasaki and Benedikt M. Kessler and Jason L. Parsons and Yong Tae Kwon and Grigory L Dianov},
  booktitle={Nucleic acids research},
  year={2012}
}
APE1 (Ref-1) is an essential human protein involved in DNA damage repair and regulation of transcription. Although the cellular functions and biochemical properties of APE1 are well characterized, the mechanism involved in regulation of the cellular levels of this important DNA repair/transcriptional regulation enzyme, remains poorly understood. Using an in vitro ubiquitylation assay, we have now purified the human E3 ubiquitin ligase UBR3 as a major activity that polyubiquitylates APE1 at… CONTINUE READING

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