Ubiquitin ligase Rad18Sc localizes to the XY body and to other chromosomal regions that are unpaired and transcriptionally silenced during male meiotic prophase.

@article{Laan2004UbiquitinLR,
  title={Ubiquitin ligase Rad18Sc localizes to the XY body and to other chromosomal regions that are unpaired and transcriptionally silenced during male meiotic prophase.},
  author={R. Van der Laan and Evert-Jan Uringa and Evelyne Wassenaar and Jos W. Hoogerbrugge and Esther Sleddens and Hanny Odijk and Henk P. Roest and Peter de Boer and Jan H. J. Hoeijmakers and J. Anton Grootegoed and Willy M Baarends},
  journal={Journal of cell science},
  year={2004},
  volume={117 Pt 21},
  pages={5023-33}
}
In replicative damage bypass (RDB) in yeast, the ubiquitin-conjugating enzyme RAD6 interacts with the ubiquitin ligase RAD18. In the mouse, these enzymes are represented by two homologs of RAD6, HR6a and HR6b, and one homolog of RAD18, Rad18Sc. Expression of these genes and the encoded proteins is ubiquitous, but there is relatively high expression in the testis. We have studied the subcellular localization by immunostaining Rad18Sc and other RDB proteins in mouse primary spermatocytes passing… CONTINUE READING

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