Ubiquitin ligase RNF167 regulates AMPA receptor-mediated synaptic transmission.

  title={Ubiquitin ligase RNF167 regulates AMPA receptor-mediated synaptic transmission.},
  author={Marc P. Lussier and Bruce E Herring and Yukiko Nasu-Nishimura and Albert Neutzner and Mariusz Karbowski and Richard J Youle and Roger A Nicoll and Katherine W. Roche},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={109 47},
AMPA receptors (AMPARs) mediate the majority of fast excitatory neurotransmission, and their density at postsynaptic sites determines synaptic strength. Ubiquitination is a posttranslational modification that dynamically regulates the synaptic expression of many proteins. However, very few of the ubiquitinating enzymes implicated in the process have been identified. In a screen to identify transmembrane RING domain-containing E3 ubiquitin ligases that regulate surface expression of AMPARs, we… CONTINUE READING
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