Ubiquitin ligase Hrd1 enhances the degradation and suppresses the toxicity of polyglutamine-expanded huntingtin.

Abstract

E3 ubiquitin ligases catalyze the conjugation of ubiquitin onto proteins, which acts as a signal for targeting proteins for degradation by the proteasome. Hrd1 is an endoplasmic reticulum (ER) membrane-spanning E3 with its catalytic active RING finger facing the cytosol. We speculated that this topology might allow Hrd1 to ubiquitinate misfolded proteins in… (More)

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Cite this paper

@article{Yang2007UbiquitinLH, title={Ubiquitin ligase Hrd1 enhances the degradation and suppresses the toxicity of polyglutamine-expanded huntingtin.}, author={Hui Yang and Xiaoyan Zhong and Petek Ballar and Shouqing Luo and Yu-xian Shen and David C Rubinsztein and Mervyn J. Monteiro and Shengyun Fang}, journal={Experimental cell research}, year={2007}, volume={313 3}, pages={538-50} }