Ubiquitin ligase Cbl-b acts as a negative regulator in discoidin domain receptor 2 signaling via modulation of its stability.

@article{Yu2014UbiquitinLC,
  title={Ubiquitin ligase Cbl-b acts as a negative regulator in discoidin domain receptor 2 signaling via modulation of its stability.},
  author={Jiangtian Yu and Hu Zhao and Yan Zhang and Yun-Cai Liu and Li-bo Yao and Xia Li and Jin Su},
  journal={FEBS letters},
  year={2014},
  volume={588 9},
  pages={1509-14}
}
Discoidin domain receptor 2 (DDR2), a collagen receptor tyrosine kinase, initiates signal transduction upon collagen binding, but little is known as to how DDR2 signaling is negatively regulated. Herein we demonstrate that Cbl family member Cbl-b predominantly promotes the ubiquitination of DDR2 upon collagen II stimulation. Cbl-b-mediated ubiquitination… CONTINUE READING