Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains.

Abstract

Neurofibrillary tangles (NFT) and neurites associated with senile plaques (SP) in Alzheimer disease-affected brain tissues were specifically immunostained with affinity-purified antibody preparations directed against ubiquitin. In addition, a class of neurites seen in brain regions containing NFT and SP were also specifically stained. Cross-reactivity of… (More)

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