Ubiquitin in chains.

@article{Pickart2000UbiquitinIC,
  title={Ubiquitin in chains.},
  author={Cecile M. Pickart},
  journal={Trends in biochemical sciences},
  year={2000},
  volume={25 11},
  pages={544-8}
}
The ubiquitin-proteasome system fulfills an essential function in eukaryotes by controlling the levels of crucial intracellular regulatory proteins. In this system, a specific type of polyubiquitin chain acts as the proximal signal for targeting substrates to 26S proteasomes for degradation. Recent results have revealed important determinants of polyubiquitin-chain recognition by proteasomes, helping to explain the biological rationale behind this novel signaling mechanism. 
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