Ubiquitin hubs in oncogenic networks.

@article{Crosetto2006UbiquitinHI,
  title={Ubiquitin hubs in oncogenic networks.},
  author={Nicola Crosetto and Marzena Bienko and Ivan Dikic},
  journal={Molecular cancer research : MCR},
  year={2006},
  volume={4 12},
  pages={
          899-904
        }
}
Ubiquitin is an important regulator of diverse biological functions including cell cycle progression, apoptosis, cell proliferation, and DNA damage responses. Crucial proteins involved in the control of such diverse functions are modified by ubiquitin and are frequently altered during oncogenesis. Here, we define such proteins as key-nodes regulated by ubiquitin, discuss examples of their oncogenic aberrations, and indicate how pharmacologic manipulation of such molecular hubs might improve… CONTINUE READING

Figures and Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-8 OF 8 CITATIONS

Role of NEDD8 in HIV-associated lipodystrophy.

  • Differentiation; research in biological diversity
  • 2009
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 35 REFERENCES

Ubiquitin ligases: cell-cycle control and cancer

  • Nature Reviews Cancer
  • 2006
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Ubiquitin signalling in the NF-κB pathway

  • Nature Cell Biology
  • 2005
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL