Ubiquitin-dependent regulation of COPII coat size and function

  title={Ubiquitin-dependent regulation of COPII coat size and function},
  author={Lingyan Jin and Kanika Bajaj Pahuja and Katherine E. Wickliffe and Amita Gorur and Christine Baumg{\"a}rtel and Randy Schekman and Michael Rape},
Packaging of proteins from the endoplasmic reticulum into COPII vesicles is essential for secretion. In cells, most COPII vesicles are approximately 60–80 nm in diameter, yet some must increase their size to accommodate 300–400 nm procollagen fibres or chylomicrons. Impaired COPII function results in collagen deposition defects, cranio-lenticulo-sutural dysplasia, or chylomicron retention disease, but mechanisms to enlarge COPII coats have remained elusive. Here, we identified the ubiquitin… CONTINUE READING
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