Ubiquitin-dependent protein degradation.

@article{Hochstrasser1996UbiquitindependentPD,
  title={Ubiquitin-dependent protein degradation.},
  author={Mark Hochstrasser},
  journal={Annual review of genetics},
  year={1996},
  volume={30},
  pages={405-39}
}
A growing number of cellular regulatory mechanisms are being linked to protein modification by the polypeptide ubiquitin. These include key transitions in the cell cycle, class I antigen processing, signal transduction pathways, and receptor-mediated endocytosis. In most, but not all, of these examples, ubiquitination of a protein leads to its degradation by the 26S proteasome. Following attachment of ubiquitin to a substrate and binding of the ubiquitinated protein to the proteasome, the bound… CONTINUE READING
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