Ubiquitin-dependent degradation of active Src

  title={Ubiquitin-dependent degradation of active Src},
  author={Yaron Hakak and G. Steven Martin},
  journal={Current Biology},
Signaling by members of the Src family of protein tyrosine kinases, such as Src and Fyn, is important in many biological responses, including gene transcription, cell-cycle progression, and cell adhesion and spreading [1] [2]. Unregulated Src kinase activity has been implicated in the progression of colon cancer and transformation of cultured cells [3] [4… CONTINUE READING