Ubiquitin-dependent degradation of HDAC4, a new regulator of random cell motility

@inproceedings{Cernotta2011UbiquitindependentDO,
  title={Ubiquitin-dependent degradation of HDAC4, a new regulator of random cell motility},
  author={Nadia Cernotta and Andrea Clocchiatti and Cristina Florean and Claudio Brancolini},
  booktitle={Molecular biology of the cell},
  year={2011}
}
HDAC4 (histone deacetylase 4) belongs to class IIa of histone deacetylases, which groups important regulators of gene expression, controlling pleiotropic cellular functions. Here we show that, in addition to the well-defined nuclear/cytoplasmic shuttling, HDAC4 activity is modulated by the ubiquitin-proteasome system. Serum starvation elicits the poly-ubiquitination and degradation of HDAC4 in nontransformed cells. Phosphorylation of serine 298 within the PEST1 sequence plays an important role… CONTINUE READING