Ubiquitin-conjugating enzymes: novel regulators of eukaryotic cells.

@article{Jentsch1990UbiquitinconjugatingEN,
  title={Ubiquitin-conjugating enzymes: novel regulators of eukaryotic cells.},
  author={Stefan Jentsch and Wolfgang Seufert and Thomas M. Sommer and H A Reins},
  journal={Trends in biochemical sciences},
  year={1990},
  volume={15 5},
  pages={195-8}
}
Covalent attachment of ubiquitin to cellular proteins is essential for cell viability and is catalysed by a set of distinct ubiquitin-conjugating enzymes. Individual members of this novel enzyme family mediate strikingly diverse functions, including DNA repair, cell cycle control, selective protein degradation and essential functions of the stress response. 

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