Ubiquitin-conjugating enzyme E2C regulates apoptosis-dependent tumor progression of non-small cell lung cancer via ERK pathway.

@article{Zhang2015UbiquitinconjugatingEE,
  title={Ubiquitin-conjugating enzyme E2C regulates apoptosis-dependent tumor progression of non-small cell lung cancer via ERK pathway.},
  author={Zhongmian Zhang and Ping Liu and Jian Wang and Tianxiao Gong and Fang Zhang and Jun Ma and Na Han},
  journal={Medical oncology},
  year={2015},
  volume={32 5},
  pages={149}
}
The oncogenic role of ubiquitin-conjugating enzyme E2C (UBE2C) had been identified in some types of human tumors, while the clinical and biological role of UBE2C in non-small cell lung cancer (NSCLC) is still elusive. Here, we have determined the specific role of UBE2C in NSCLC. Western blot and qRT-PCR were used for detecting the mRNA level and protein level of UBE2C in NSCLC samples and cell lines, respectively. Lentivirus product was used to conduct loss of function assay. qRT-PCR array was… CONTINUE READING

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